High Resolution Mapping of Lower Urinary Tract Innvervation During Development
Grant number: 3UO1DK094479-04S1 | Funding period: 2013 - 2015
Completed
Abstract
DESCRIPTION (provided by applicant): The primary behaviors of the mature lower urinary tract (LUT) - storage and voiding depend on a functional nervous system. Development of these circuits in the prenatal period is poorly understood. Postnatal, there is a dramatic transition frm the immature situation where voiding is automatic, i.e., not controlled by brain-driven processes, to the healthy mature system where filling triggers a conscious need to void, but micturition is determined voluntarily at an appropriate time and place. Around puberty, further changes occur to coordinate bladder, bowel and sexual activity. Many events occur in the nervous system over these periods, although the cellu..
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